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Genome-wide fork-collapse sites in MEFs from ATR inhibition

ABSTRACT: Transient obstruction of DNA polymerase progression activates the ATR checkpoint kinase, which suppresses fork breakage, strand resection, and RPA accumulation. Herein, we use RPA ChIP-Seq to identify replication-problematic loci (RPLs) across the mammalian genome from ATR inhibition.

ORGANISM(S): Mus musculus

PROVIDER: GSE100790 | GEO | 2018/10/04

REPOSITORIES: GEO

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