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Mycobacterium tuberculosis hijacks host primary transcripts

ABSTRACT: Intracellular pathogens requires efficient mechanism adapting the environment inside of host cells. Here we show that the transcriptomes of the cellular mycobacterium tuberculosis and of those released from the infected macrophage cells contain a large fraction of human transcripts by RNA polymerase II. Uptake of host pre-mRNAs is coincident with the co-localization of M. tuberculosis with nuclear membrane. The infective M. tuberculosis selectively uptakes snoRNAs.The intracellular pathogens has a preferable capability in taking pre-mRNAs. The host transcripts are not generally spliced nor translated.We suggest that the intracellular bacterium has acquired a mechanism to take transcripts from the host cell nuclus as its own nutrient supply and may help them to survive with hosts.

ORGANISM(S): Homo sapiens Mycobacterium tuberculosis M1458 Mycobacterium tuberculosis variant bovis BCG str. Tokyo 172

PROVIDER: GSE100897 | GEO | 2021/10/23

REPOSITORIES: GEO

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