Genomics

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Comparison of the specificities of the RGG/RG-domains of FMR1, FXR1 and FXR2 for small RNA


ABSTRACT: In previous studies, we identified a sequence motif (GDCGG) in almost all microRNAs downregulated in the serum of patients with amyotrophic lateral sclerosis. We found that FMR1, FXR1 and FXR2 directly and specifically interact with microRNAs containing the GDCGG motif via their RGG/RG-domains. Here, we compare the specificities for microRNAs of the RGG/RG-domains of FMR1, FXR1 and FXR2 on a transcriptome-wide scale using the Affymetrix GeneChip™ miRNA 3.0 Arrays.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE101067 | GEO | 2021/04/21

REPOSITORIES: GEO

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