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Microarray expression data from leukemia cell lines RS4;11 and REH with CASC15 KD or KO respectively

ABSTRACT: Long non-coding RNAs play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Here, we assess the role of lncRNA CASC15 in RUNX1/AML translocated leukemia. Differentially regulated genes following CASC15 knockdown were enriched for predicted transcriptional targets of the Yin and Yang-1 (YY1) transcription factor. Our findings represent the first characterization of this CASC15 in RUNX1-translocated leukemia, and point towards a mechanistic basis for its action. We used microarrays to look at significantly differentally expressed genes and global effectes upon knockdown of knockout of CASC15 in two different leukemia cell lines

ORGANISM(S): Homo sapiens

PROVIDER: GSE101149 | GEO | 2017/07/12

SECONDARY ACCESSION(S): PRJNA393818

REPOSITORIES: GEO

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