Pathophysiology and therapeutics of arrhythmogenic right ventricular cardiomyopathy 5

ABSTRACT: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibro-fatty replacement of the myocardium that causes heart failure and sudden cardiac death. The most aggressive subtype of ARVC is ARVC type 5 (ARVC5), caused by a p.S358L mutation in TMEM43. The function and localization of TMEM43 and the mechanism by which the p.S358L mutation causes the disease, are unknown.

ORGANISM(S): Mus musculus

PROVIDER: GSE101301 | GEO | 2019/07/12

REPOSITORIES: GEO