Transcriptomics

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Neurog3-Cre p300/CBP mouse islets RNA-seq


ABSTRACT: We have performed RNA-seq on mouse islets lacking all p300 (p300 KO), all CBP (CBP-null), and one copy of CBP and all p300 (triallelic). The data revealed that p300 and CBP regulate some distinct but largely overlapping genes in islets. This was further confirmed by GO term and transcription factor target analyses, which suggested that these coactivators regulate genes that function similarly and converge to Hnf1a pathway.

ORGANISM(S): Mus musculus

PROVIDER: GSE101537 | GEO | 2017/12/11

SECONDARY ACCESSION(S): PRJNA394750

REPOSITORIES: GEO

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