Methylation profiling

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DNA Methylation alterations following binge-like developmental ethanol exposure assessed in 21 day-old mice


ABSTRACT: This experiment is an application of MeDIP-seq on hippocampus in a mouse model of fetal alcohol spectrum disorder (FASD). Here, we investigate genome-wide changes in DNA methylation in six C57BL/6 mice (3 ethanol-exposed and 3 saline-exposed). Mice were injected with either ethanol or saline on postnatal days 4 and 7, with hippocampal DNA methylation assessed on postnatal day 21. Across the six mice, there are 151,911 MeDIP peaks mapped to “intergenic”, “gene body”, or “promoter” based on the DNAm peaks proximity to a gene. Of these locations, 18,992 regions (16,374 intergenic, 1,887 gene body, 661 promoter) were common in all six mice (113,532 total) and can be combined for further analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE101636 | GEO | 2017/07/20

SECONDARY ACCESSION(S): PRJNA395044

REPOSITORIES: GEO

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