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Functional and genomic characterization of a xenograft model system for the study of metastasis in triple-negative breast cancer.

ABSTRACT: To define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four isogenic populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101745 | GEO | 2018/02/01

REPOSITORIES: GEO

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