Transcriptomics

Dataset Information

0

Somatic ACE regulates self-renewal of mouse spermatogonial stem cell via MAPK signaling pathway


ABSTRACT: To further explore the mechanism involved in sACE mediated SSCs proliferation. We established microarray gene expression profiles with or without captopril treatment in cultured SSCs and identified 651 differentially expressed genes (Fold Change>2, P<0.05). Among them, 297 genes were remarkably upregulated and 354 genes were downregulated in three comparison groups after captopril treatment.Then bioinformatical analysis including GO analysis and KEGG pathway analysis were performed and both of them indicated these differentially expressed genes might be involved in regulation of tyrosine phosphorylation of STAT protein, ERK1 and ERK2 cascade, MAPK signaling, Jak-STAT signaling and et al. Four MAPK signaling related genes (Pla2g12b, Cacna2d1, Dusp2, Fgf3) from this signature was quantified by real-time PCR.

ORGANISM(S): Mus musculus

PROVIDER: GSE101752 | GEO | 2019/01/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2009-12-03 | GSE19286 | GEO
2015-09-30 | GSE66656 | GEO
2009-12-14 | E-GEOD-19286 | biostudies-arrayexpress
2013-05-14 | E-GEOD-46871 | biostudies-arrayexpress
2013-05-14 | GSE46871 | GEO
2015-11-11 | E-MTAB-2102 | biostudies-arrayexpress
2020-06-29 | GSE144085 | GEO
2013-05-01 | E-GEOD-44363 | biostudies-arrayexpress
2013-05-01 | GSE44363 | GEO
2020-10-26 | GSE160061 | GEO