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Cerebellar abiotrophy in working Kelpies with a later clinical onset

ABSTRACT: Australian working Kelpie dogs are known to be affected with an autosomal recessive form of inherited cerebellar ataxia (cerebellar abiotrophy, CA) that is characterised by a degeneration of Purkinje and granule cells in the cerebellar cortex. The clinical signs of CA include cerebellar ataxia, head tremor, motor in-coordination, wide based stance and high stepping gait, with varied clinical onset age. The clinical and pathological features are similar to cerebellar ataxias in humans. The genome-wide association study on a group of working Kelpies affected with the later onset form of CA identified a region on chromosome 9 to be strongly associated with the disease phenotype. Homozygosity analysis and whole genome sequencing identified a missense single nucleotide polymorphism, that segregated with the CA phenotype.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE102154 | GEO | 2022/12/31

REPOSITORIES: GEO

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Canis lupus familiaris

Project description:Cerebellar abiotrophy in working Kelpies with a later clinical onset

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