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Expression analysis of melanocyte stem cells from Mitfmi-vga9/+ mice reveals a role for MITF in the transcriptional regulation of innate immune gene expression

ABSTRACT: Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants of hair graying, we found that the Mitfmi-vga9/+ strain of mice is susceptible to loss of McSC maintenance via ectopic McSC differentiation. Based on transcriptome and molecular analyses of Mitfmi-vga9/+ mice we report a novel role for MITF in the regulation of systemic innate immune gene expression. We also demonstrate that viral mimic (poly I:C) is sufficient to expose genetic susceptibility to hair graying. These observations point to a critical suppressor of innate immunity and the consequences of its dysregulation, and for melanocytes, both may have particular implications for the autoimmune, depigmenting disease vitiligo.

ORGANISM(S): Mus musculus

PROVIDER: GSE102271 | GEO | 2018/02/04

REPOSITORIES: GEO

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