Transcriptomics

Dataset Information

0

H2AX controls motor learning and response to oxidative stress


ABSTRACT: ATM drives DNA repair through rapid phosphorylation of the histone variant H2AX. Similarities between ATM and H2AX are evident in the phenotypes of their knockout mouse models, but the role of H2AX in the brain remains obscure. Here, we provide the first evidence that H2AX loss leads to neurobehavioral deficits. H2AX regulates proper response to oxidative stress through Nrf2-transcriptional targets and treatment with antioxidant ameliorates the neurobehavioral deficits.

ORGANISM(S): Mus musculus

PROVIDER: GSE102548 | GEO | 2018/03/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2015-11-04 | E-GEOD-63861 | biostudies-arrayexpress
2015-11-04 | GSE63861 | GEO
2012-04-04 | GSE25577 | GEO
2020-12-15 | PXD016586 | Pride
2014-04-01 | GSE44309 | GEO
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
2009-12-01 | GSE18191 | GEO
2014-04-01 | E-GEOD-44309 | biostudies-arrayexpress
2015-04-25 | GSE68233 | GEO
2013-01-16 | GSE43498 | GEO