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Circular RNAs show differential expression profiles and may be potential therapeutic targets by acting as ceRNAs in cholesteatoma

ABSTRACT: In our present study, we explored the circRNA expression profiles in cholesteatoma by deep RNA-seq analysis. We obtained totally 355 significantly differentially expressed circRNA in cholesteatoma, among which 101 were identified to be up-regulated, and 254 down-regulated. By constructing the circRNA-miRNA-mRNA ceRNA networks, it was discovered that circRNAs might contribute to cholesteatoma formation by functioning as ceRNAs for miRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102715 | GEO | 2020/04/27

REPOSITORIES: GEO

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