Transcriptomics

Dataset Information

0

Sp8 and Sp9 Coordinately Promote Striatal Medium Spiny Neuron Production through Activating Six3 Expression [RNA-seq]


ABSTRACT: Purpose: To assess changes in gene expression profiles from the E16.5 no cre littermate control striatum and conditional double knockout of Dlx5/6-CIE; Sp8 Flox/Flox; Sp9 Flox/Flox mice. Methods: Total RNA was isolated and sequenced from the striatum of the E16.5 no cre littermate control or Dlx5/6-CIE; Sp8 Flox/Flox; Sp9 Flox/Flox mice in duplicate using an illumina high-seq 2500. Raw data was analyzed using TopHat. Genes were considered changed which performed fold-change>=2 and FDR<=0.05. Changed genes were then filtered to reveal the downstream targets of Sp8 and Sp9. Results: 80 genes were significantly increased and 120 genes were significantly decreased in expression level due to the loss of Sp8 and Sp9 expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE102865 | GEO | 2018/05/11

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-09-03 | GSE86396 | GEO
2017-01-04 | GSE93061 | GEO
2016-06-16 | E-GEOD-83373 | biostudies-arrayexpress
2016-06-16 | GSE83373 | GEO
2016-09-29 | GSE87416 | GEO
2018-05-11 | GSE114306 | GEO
2022-07-06 | GSE202550 | GEO
2022-07-06 | GSE202523 | GEO
2021-02-01 | GSE144732 | GEO
2021-02-01 | GSE144731 | GEO