Expression data of miRNA from parental B16F0 cells and B16F0 exosomes [miRNA]
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ABSTRACT: As a type of secreted membrane vesicle, exosomes are emerging as an important mode of cell-to-cell communication. The objective of this study was to compare the abundance of mRNA and miRNA present in the parental B16F0 cell to mRNA and miRNA present in exosomes isolated from B16F0 conditioned media. Identifying local mechanisms of immunosuppression is a key barrier for expanding the clinical benefit of cancer immunotherapy. While exosomes are emerging as a new mode of intercellular communication, their role in establishing a malignant tissue niche remains unclear. Similar to the sculpting of tumor antigens during oncogenesis, a related hypothesis is that proteins secreted by malignant cells are shaped by somatic evolution. To test this hypothesis, we characterized the biological influence of tumor-derived exosomes on immune cell function.
ORGANISM(S): synthetic construct Mus musculus
PROVIDER: GSE102883 | GEO | 2019/08/01
REPOSITORIES: GEO
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