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Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling [Affymetrix]

ABSTRACT: In the field of MDS and on bone marrow mononuclear cells , we search for a signature which predict the response to Lenalidomide treatment. This transcriptome study appended to the GFM-LEN-EPO-2008 clinical trial reports a predictive signature of response to lenalidomide and a unique immune response signature after treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE102976 | GEO | 2017/08/24

REPOSITORIES: GEO

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Differential response to Lenalidomide from WT and RUNX1-KO MDS-L del(5q) cells

Project description:We used CRISPR/Cas9 system to generate WT Control and RUNX1-KO MDS-L cells isolated as single clones from the parental MDS-L cell line. We have observed that RUNX1-KO MDS-L cells are resistant to Lenalidomide-induced cell death compared to WT Control MDS-L cells We have treated WT and RUNX1-KO MDS-L cells with 1µM Lenalidomide for 24h or 72h and performed expression analysis

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Lenalidomide Resistance in del(5q) Myelodysplastic Syndrome Follows Loss of RUNX1/TP53-mediated Megakaryocytic Differentiation

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Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling [Affymetrix]

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Project description: Not available

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Affymetrix SNP array data for myelodysplastic syndrome with 5q deletion treated with lenalidomide

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Project description:Differential response to Lenalidomide from WT and RUNX1-KO MDS-L del(5q) cells

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