DNA microarray analysis in hippocampus of Wild-type (WT), AtrxΔE2, and 5-aminolevulinic acid (5-ALA) treated AtrxΔE2 mice.
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ABSTRACT: 5-ALA that can be metabolized to porphyrins, protoporphyrin IX and hemin antagonizes decreased synaptic plasticity and cognitive deficits seen in ATR-X model (AtrxΔE2) mice. Our findings suggest a potential therapeutic strategy to target G-quadruplexes and decrease cognitive impairment associated with ATR-X syndrome.
ORGANISM(S): Mus musculus
PROVIDER: GSE103031 | GEO | 2018/01/28
REPOSITORIES: GEO
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