Transformation of NIH3T3 cells by the forced expression of wild-type YAP or its stabilized form

ABSTRACT: YAP is known as a proto-oncogene with which the aberrant expression causes numerous types of cancer. To elucidate the molecular mechanisms underlying the acquisition of cancerous traits of normal cells by YAP overexpression, the wild-type YAP or its stabilized form was overexpressed in NIH3T3 cells. We found that the forced expression of either wild-type YAP or its derivative alone was sufficient for transforming NIH3T3 cells and we then analyzed the global expression profiles of the control NIH3T3 cells or those overexpressing wild-type or stabilized YAP.

ORGANISM(S): Mus musculus

PROVIDER: GSE103499 | GEO | 2019/08/21

REPOSITORIES: GEO