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Effects of two weeks of intermittent hypoxia on liver and adipose tissue in lean mice,

ABSTRACT: Lean mice were submitted to either normoxia (controls) or CIH (CIH+) for 14 days. We analyzed liver and epidydimal adipose tissue signatures using transcriptomic analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE104128 | GEO | 2017/09/23

SECONDARY ACCESSION(S): PRJNA411778

REPOSITORIES: GEO

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Expression data from mouse aorta with chronic intermittent hypoxia exposure

Project description:Atherosclerosis is the pathological basis of cardiovascular disease. Obstructive sleep apnea aggravates atherosclerosis, and chronic intermittent hypoxia (CIH) as a prominent feature of obstructive sleep apnea plays an important role during the process of atherosclerosis. The mechanisms of CIH in the development of atherosclerosis remain unclear. The microarray was used to investigate differentially expressed mRNAs and long noncoding RNAs (lncRNAs) in aorta from five groups of ApoE-/- mice fed with a high-fat diet and exposed to various conditions: normoxia for 8 weeks, CIH for 8 weeks, normoxia for 12 weeks, CIH for 12 weeks, or CIH for 8 weeks followed by normoxia for 4 weeks.

2020-02-14 | GSE145221 | GEO

Chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation, and exacerbates Alzheimer’s-like memory and synaptic plasticity deficits and molecular signatures

Project description:Obstructive sleep apnea (OSA), characterized by sleep fragmentation and chronic intermittenthypoxia (CIH), is a risk factor for Alzheimer’s disease (AD) progression. Recent epidemiologicalstudies point to CIH as the best predictor of developing cognitive decline and AD in elderly withOSA. However, the precise underlying mechanism(s) remain unknown. The present study wasundertaken to evaluate the effect of CIH on pathological human tau seeding, propagation, andaccumulation, cognition, synaptic plasticity, neuronal network excitability, and gene expressionprofiles in a P301S human mutant tau mouse model of AD and related tauopathies. We exposed 4-4.5-month-old, male, P301S and WT mice to an 8-week CIH protocol (6 min cycle:21% O 2 to 8% O 2 to 21% O 2 , 80 cycles per 8 h during daytime), and assessed its effect on taupathology and various AD-related phenotypic and molecular signatures. Age- and gender-matched P301S and WT mice were reared in normoxia (21% O 2 ) as experimental controls. CIH significantly enhanced pathological human tau seeding and spread across connected brain circuitry in P301S mice; it also increased phospho-tau load. CIH also exacerbated memory and synaptic plasticity deficits in P301S mice. However, CIH had no effect on seizure susceptibility and network hyperexcitability in these mice. Finally, CIH exacerbated AD-related pathogenic molecular signaling in P301S mice. CIH-induced increase in pathologic human tau seeding and spread and exacerbation of other AD- related impairments provide new insights into the role of CIH and OSA in AD pathogenesis.

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Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia

Project description:Chronic constant hypoxia (CCH), such as in pulmonary diseases or high altitude, and chronic intermittent hypoxia (CIH), such as in sleep apnea, can lead to major changes in the heart. The molecular mechanisms underlying these cardiac alterations are not well understood. We hypothesized that analysis on the changes in gene expression could help to delineate such mechanisms. In addition, the differences that can be anticipated between CCH and CIH could be potentially dissected. Current study used CCH and CIH mouse models combined with cDNA microarrays to determine the changes of gene expression in CCH or CIH mice heart. Keywords = heart Keywords = hypoxia Keywords = mouse Keywords = microarray Keywords: time-course

2010-06-10 | E-GEOD-2271 | biostudies-arrayexpress

Effects of two weeks of intermittent hypoxia on liver and adipose tissue in lean mice,

Project description:Effects of two weeks of intermittent hypoxia on liver and adipose tissue in lean mice,

| PRJNA411778 | ENA

Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia

2005-04-18 | GSE2271 | GEO

Changes in the hippocampal proteome of chronic intermittent hypoxia mice

Project description:Cognitive and behavioural scales have indicated chronic intermittent hypoxia (CIH)-induced abnormalities in learning, memory, and cognition . Although earlier studies have shown that CIH impacts adult hippocampal neurogenesis and cognitive processes, the exact mechanism through which CIH affects hippocampal function, particularly learning and memory, remains unclear. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the proteome of the hippocampus in mice exposed to CIH for or normoxia for 4 weeks. We identified 5729 proteins in the hippocampi of CIH and CON mice, 4878 of which were quantified via proteomic spectrogram analysis. Although numerous proteins were identified, only 21 proteins exhibited significant differences. In biological processes (BP) analysis, the majority of proteins were enriched in phagocytosis and immune response, especially in B cells. Furthermore, in the analysis of cellular components (CC), most of proteins showed enrichment in immunoglobulin complexes. Finally, in the analysis of molecular functions (MFs), a notable enrichment of these proteins in immunoglobulin receptor-binding activities was observed.

2024-02-07 | PXD049225 |

Acetylome analyses provide new insights into the effect of chronic intermittent hypoxia on hypothalamus-dependent endocrine metabolism impairment

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2024-10-17 | PXD051767 | Pride

Characterization of lysine acetylome in mice subjected to chronic intermittent hypoxia

Project description:Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behaviour remain poorly understood. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the lysine acetylome of the hippocampus in healthy adult mice exposed to intermittent hypoxia for 4 weeks (as a CIH model) and in normoxia mice (as a control). We identified and quantified 2184 lysine acetylation sites in 1007 proteins. CIH differentially regulated 280 acetylated sites on 213 proteins, with 35.21% of acetylated proteins annotated in mitochondria. Analysis of these acetylated proteins revealed disturbances primarily in oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, and glycolysis, all of which are localized exclusively to mitochondria.

2024-02-07 | PXD049226 |

Comprehensive analysis of differentially expressed miRNAs in mice with kidney injury induced by chronic intermittent hypoxia

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2022-10-20 | GSE202480 | GEO

Gene expression profile in the pons-medulla (brainstem) of male mice during Chronic Intermittent Hypoxia and Normoxia

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