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Gene expression profiling of WT and STAT3-/- Tc17 CD8+ T cells

ABSTRACT: CD8+ T cells are pre-programmed for cytotoxic differentiation. However, a subset of effector CD8+ T cells (‘Tc17’) produce IL-17 and fail to express cytotoxic genes. Here, we show that the transcription factors directing IL-17 production inhibit cytotoxicity despite persistent Runx3 expression. Cytotoxic gene repression did not require the transcription factor Thpok. We further show that STAT3 restrained cytotoxic gene expression in CD8+ T cells and that RORgt represses cytotoxic genes by inhibiting the functions but not the expression of the ‘cytotoxic’ transcription factors T-bet and Eomesodermin. Thus, the transcriptional circuitry directing IL-17 expression inhibits cytotoxic functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE104144 | GEO | 2017/11/27

SECONDARY ACCESSION(S): PRJNA411814

REPOSITORIES: GEO

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