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Macrophages mediate systemic tissue health after remote injury

ABSTRACT: Functions of tissue-resident macrophages in the steady state and after direct injury to the vital organs they inhabit are currently emerging. Yet, whether macrophages react to injury systemically and remotely, for instance how lung, liver or renal macrophages respond to myocardial infarction and stroke, remains obscure. Here we report that after myocardial infarction, stroke and peritonitis, macrophage populations expand in most distant organs through local cell proliferation and recruitment. Transcriptome profiling reveals a profound, system-wide response of macrophages to remote injury in all organs. This response is determined by the host organ rather than by injury type.

ORGANISM(S): Mus musculus

PROVIDER: GSE104342 | GEO | 2019/08/31

REPOSITORIES: GEO

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