Transcriptomics

Dataset Information

0

The Nasal Methylome: A Key to Understanding Allergic Asthma [Agilent]


ABSTRACT: The goal of this investigation was to establish proof of concept that nasal epithelium can be used as a proxy for the airway epithelium in studies of allergic asthma. We collected PBMCs, nasal epithelia, and bronchial epithelia from 12 subjects with allergic asthma and 12 control subjects without asthma, all non-Hispanic white nonsmoker adults. We conclude that genomic profiling of nasal epithelia captures most disease-relevant changes identified in airway epithelia but also provides additional targets that are most likely influenced by exposures. Thus, epigenetic marks in nasal epithelia may prove useful as a biomarker of disease severity and response to treatment or as a biosensor of the environment in asthma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE104468 | GEO | 2017/10/02

SECONDARY ACCESSION(S): PRJNA412792

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2017-10-02 | GSE104471 | GEO
2013-10-18 | E-GEOD-51392 | biostudies-arrayexpress
2012-01-05 | E-GEOD-19187 | biostudies-arrayexpress
2015-11-01 | E-GEOD-65163 | biostudies-arrayexpress
2013-10-18 | GSE51392 | GEO
2013-02-05 | E-GEOD-44037 | biostudies-arrayexpress
2015-11-01 | GSE65163 | GEO
2015-10-23 | E-GEOD-41861 | biostudies-arrayexpress
2012-01-05 | GSE19187 | GEO
2012-01-05 | E-GEOD-19182 | biostudies-arrayexpress