Transcriptomics

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Poly(A) Tail Length of L4 C. elegans


ABSTRACT: Poly(A) tails are important elements in mRNA translation and stability. However, recent genome-wide studies concluded that poly(A) tail length was generally not associated with translational efficiency in non-embryonic cells. To investigate if poly(A) tail size might be coupled to gene expression in an intact organism, we used an adapted TAIL-seq protocol to measure poly(A) tails in Caenorhabditis elegans. Surprisingly, we found that well-expressed transcripts contain relatively short, well-defined tails. This attribute appears dependent on translational efficiency, as transcripts enriched for optimal codons and ribosome association had the shortest tail sizes, while non-coding RNAs retained long tails.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE104501 | GEO | 2017/10/19

SECONDARY ACCESSION(S): PRJNA412860

REPOSITORIES: GEO

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