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Gene expression profiling in liver normal and tumor tissues in C3H mice

ABSTRACT: We have employed microarray analysis to detect tumor-related genes of liver tissues in C3H mice

ORGANISM(S): Mus musculus

PROVIDER: GSE104627 | GEO | 2018/04/04

REPOSITORIES: GEO

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The DNA methylation profiles of liver tissues (normal, non-tumor and tumor tisuues) of F2 males of C3H mice born to F1 mice gestationally exposed to arsenite

Project description:Background: Previously, we showed that gestational arsenite (As) exposure of F0 females increases hepatic tumors in the F2 males in C3H mice. However, the mechanisms have not yet been clarified. Methods: We detected genome wide site-specific DNA methylation by using reduced representative bisulfite sequence (RRBS) method. We used the data uploaded here and those with GSE Series accession number GSE111420 (CCN and CCTt) to detect differential methyrated cytosines between control groups and arsenite groups. Results: We clarified that DNA methylation of Tmem54 and Cd74 around TSS were downregulated and their gene expressions were accordingly upregulated in the liver tumor tissues of F2 males of arsenite group. Conclusions: Our study proposes novel DNA methylation dependent pathways which increase liver tumors in the F2 males of arsenite group.

2019-08-20 | GSE123749 | GEO

Gene expression profiling in liver normal and tumor tissues in C3H mice

Project description:Gene expression profiling in liver normal and tumor tissues in C3H mice

| PRJNA413369 | ENA

Gene expression profiles of liver tissues (normal, non-tumor and tumor tisuues) of F2 males of C3H mice born to F1 mice gestationally exposed to arsenite

Project description:We have employed microarray analysis to detect gene expression changes that were affected in the F2 mice of arsenite group.

2019-08-20 | GSE123737 | GEO

Transcriptome of the liver in 15-day-old C3H/HeJ mice

Project description:Male C3H/HeOuJ mice are susceptible to spontaneous liver neoplasms. We collected liver samples from young, tumour-free mice for control experiments. Liver tissue samples were snap frozen in liquid nitrogen and total RNA was extracted using the AllPrep 96 DNA/RNA Kit (Qiagen) according to the manufacturer’s instructions. Libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina) and sequenced in an Illumna HiSeq4000 to produce 150bp paired-end reads.

2018-07-29 | E-MTAB-6972 | biostudies-arrayexpress

C57BL/6 C3H/HeJ apoE-/- mice - gene expression in aorta

Project description:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit a marked difference in their susceptibility to atherosclerosis and the arterial wall has proven to be a source of the difference in atherosclerosis susceptibility. Genome-wide gene expression analysis was conducted in aortic walls of the two strains. Total RNA was extracted from aortas of 6-week-old female B6 and C3H apoE-deficient (apoE-/-) mice fed a chow or Western diet. 1514 genes in chow fed mice and 590 genes in Western fed mice were found to be differentially expressed between the two strains. RNA was extracted from aorta using a Trizol protocol. Total RNA was pooled in an equal amount from 4 mice for each group. Standard Affymetrix procedures were performed using 8ug of total RNA. Microarrays were used to detect gene expression in aortic walls of two apoE-deficient mouse strains when fed a chow or western diet. Keywords: atherosclerosis, arterial walls, C57BL/6, C3H/HeJ, Inbred strains, Hyperlipidemia, and Western diet

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Transcriptome profiles of C3H/HeJ mouse liver tumours

Project description:Transcriptome profiles of C3H/HeJ mouse liver tumours

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Bglu3 congenic mice - gene expression in liver

Project description:A congenic line was constructed by introgressing a C3H chromosome 1 region harboring Bglu3 into C57BL/6 apoE-/- background. RNA was extracted from liver using a QIAGEN kit . Total RNA was pooled in an equal amount from 3 mice for each group. Standard Affymetrix procedures were performed using 8ug of total RNA. Microarrays were used to detect gene expression in the liver of Bglu3 congenic mice and C57BL/6 apoE-deficient mouse strains fed a western diet.

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Transcriptome of the liver in 15-day-old C3H/HeJ mice

Project description:Transcriptome of the liver in 15-day-old C3H/HeJ mice

| PRJEB27613 | ENA

Lungs from ovalbumen sensitized and challenged C3H mice

Project description:Profile of gene expression in lungs of ovalbumen sensitized and challenged C3H mice. Keywords = C3H, lung, ovalbumen, mouse, Mus musculus, mice Keywords: parallel sample

2003-06-10 | GSE446 | GEO

Whole-transcriptome of the liver in 15-day-old C3H/HeOuJ and CAST/EiJ mice.

Project description:Male C3H/HeOuJ and CAST/EiJ mice were treated with diethylnitrosamine to induce liver tumours. We collected liver samples from untreated P15 mice for control experiments. Liver tissue samples were snap frozen in liquid nitrogen and total RNA was extracted using the AllPrep 96 DNA/RNA Kit (Qiagen) according to the manufacturer’s instructions. Libraries were prepared using the TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina) and sequenced on an Illumna HiSeq4000 to produce 150bp paired-end reads.

2020-06-18 | E-MTAB-8518 | biostudies-arrayexpress

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