Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE104705 | GEO | 2018/03/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Project description:Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compare the genome-wide enrichment of H4K16ac in the lateral temporal lobe of AD individuals against both younger and elderly cognitively normal controls. We found that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. Our analysis highlights the presence of three classes of AD-related changes with distinctive functional roles. Furthermore, we discovered an association between the genomic locations of significant H4K16ac changes with genetic variants identified in prior AD genome-wide association studies and with expression quantitative trait loci. Our results establish the basis for an epigenetic link between aging and AD.

| S-EPMC6124498 | biostudies-literature

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease [RNA-Seq]

Project description:Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compared the genome-wide enrichment of H4K16ac in the lateral temporal lobe of AD individuals against both younger and elderly cognitively normal controls. We find that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. Our analysis highlights the presence of three classes of AD-related changes having distinctive functional roles. Furthermore, we discover an association between the genomic locations of significant H4K16ac changes with genetic variants (SNPs) identified in prior AD genome-wide association studies (GWAS) and with expression quantitative trait loci (eQTLs). Our results establish the basis for an epigenetic link between aging and AD.

2018-03-07 | GSE104704 | GEO

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease [ChIP-Seq]

Project description:Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compared the genome-wide enrichment of H4K16ac in the lateral temporal lobe of AD individuals against both younger and elderly cognitively normal controls. We find that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. Our analysis highlights the presence of three classes of AD-related changes having distinctive functional roles. Furthermore, we discover an association between the genomic locations of significant H4K16ac changes with genetic variants (SNPs) identified in prior AD genome-wide association studies (GWAS) and with expression quantitative trait loci (eQTLs). Our results establish the basis for an epigenetic link between aging and AD.

2018-03-07 | GSE84618 | GEO

Genomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington's disease

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-20 | E-GEOD-44855 | biostudies-arrayexpress

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

Project description:Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

| PRJNA413544 | ENA

Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging.

Project description:Alzheimer's disease (AD) is an age-related neurodegenerative disease with unknown mechanism that is characterized by the aggregation of abnormal proteins and dysfunction of immune responses. In this study, an integrative approach employing in silico analysis and wet-lab experiment was conducted to estimate the degrees of innate immune system relevant gene expression, neurotoxic Aβ42 generation and neuronal apoptosis in normal Drosophila melanogaster and a transgenic model of AD. Results demonstrated mRNA levels of antimicrobial peptide (AMP) genes gradually increased with age in wild-type flies, while which exhibited a trend for an initial decrease followed by subsequent increase during aging in the AD group. Time series and correlation analysis illustrated indicated a potential relationship between variation in AMP expression and Aβ42 concentration. In conclusion, our study provides evidence for abnormal gene expression of AMPs in AD flies with age, which is distinct from the expression profiles in the normal aging process. Aberrant AMP expression may participate in the onset and development of AD by inducing or accelerating Aβ deposition. These findings suggest that AMPs may serve as potential diagnostic biomarkers and therapeutic targets. However, further studies are required to elucidate the pathological effects and underlying mechanisms of AMP dysregulation in AD progression.

| S-EPMC6977672 | biostudies-literature

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease [RNA-Seq]

Project description:Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease [RNA-Seq]

| PRJNA413568 | ENA

Genomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington's disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-06-20 | GSE44855 | GEO

Effects of BDNF in Rodent Models of Aging and Alzheimer's Disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-01-30 | GSE14522 | GEO

Role of TET1-mediated epigenetic modulation in Alzheimer's disease

Project description:This SuperSeries is composed of the SubSeries listed below.