Genomics

Dataset Information

0

Regulation of mesenchymal stem to transit amplifying cell transition in the continuously growing mouse incisor [Histone ChIP]


ABSTRACT: Regulation of transit amplifying cell formation from self-renewing stem cell is fundamental process for cell replacement in a controlled way. Here we analyse the properties of a population of mesenchymal TACs in the continuously growing mouse incisor to identify key components of the molecular regulation that drives proliferation. We show that the polycomb repressive complex 1 acts as a global regulator of the TAC phenotype by its direct action on the expression of key cell cycle regulatory genes and also by regulating Wnt/b-catenin signalling activity. We also identify an essential requirement for TACs in maintaining the mesenchymal stem cells, indicative of a positive feedback mechanism. Analysing the properties of mesenchymal transit amplifying cells population and identifing key components of the molecular regulation that drives proliferation.

ORGANISM(S): Mus musculus

PROVIDER: GSE104891 | GEO | 2019/03/12

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-03-12 | GSE104892 | GEO
2019-03-12 | GSE104934 | GEO
2014-09-30 | E-GEOD-61505 | biostudies-arrayexpress
2014-09-30 | GSE61505 | GEO
2014-09-30 | E-GEOD-61430 | biostudies-arrayexpress
| PRJNA414098 | ENA
2014-09-30 | GSE61430 | GEO
| PRJNA414106 | ENA
| PRJNA414186 | ENA
| PRJNA414105 | ENA