Differentially Expressed Genes upon Knockdown of ZRANB1 or EZH2 in LM2 Cells
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ABSTRACT: EZH2, the catalytic component of the Polycomb repressive complex 2 (PRC2), silences gene transcription by methylating histone H3 at lysine 27. Recently we identified ZRANB1 as the EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. To determine whether ZRANB1 is a functional regulator of EZH2, we performed RNA-Seq analysis to compare the effect of ZRANB1 knockdown or EZH2 knockdown on global gene expression.
ORGANISM(S): Homo sapiens
PROVIDER: GSE104910 | GEO | 2018/04/18
REPOSITORIES: GEO
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