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H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE105456 | GEO | 2017/10/23

SECONDARY ACCESSION(S): PRJNA415202

REPOSITORIES: GEO

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H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.

Project description:Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until term and then surmounts this state to enter labor. Here, we show that dynamic generation and erasure of the repressive histone modification tri-methyl histone H3 lysine 27 (H3K27me3) in decidual stromal cells dictate both elements of pregnancy success in mice. In early gestation, H3K27me3-induced transcriptional silencing of select gene targets ensured uterine quiescence by preventing the decidua from expressing parturition-inducing hormone receptors, manifesting type 1 immunity, and most unexpectedly, generating myofibroblasts and associated wound-healing responses. In late gestation, genome-wide H3K27 demethylation allowed for target gene upregulation, decidual activation, and labor entry. Pharmacological inhibition of H3K27 demethylation in late gestation not only prevented term parturition, but also inhibited delivery while maintaining pup viability in a noninflammatory model of preterm parturition. Immunofluorescence analysis of human specimens suggested that similar regulatory events might occur in the human decidua. Together, these results reveal the centrality of regulated gene silencing in the uterine adaptation to pregnancy and suggest new areas in the study and treatment of pregnancy disorders.

| S-EPMC5749543 | biostudies-literature

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [RNA-seq]

Project description:Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a non-contractile state until term and then surmounts this state to enter labor. Here, we show in mice that dynamic deposition and removal of repressive H3K27me3 chromatin marks in decidual stromal cells dictate both elements of pregnancy success. In early gestation, H3K27me3-induced transcriptional silencing of select gene targets insures uterine quiescence by preventing the decidua from expressing parturition-inducing hormone receptors, manifesting type 1 immunity, and, most unexpectedly, generating myofibroblasts and associated wound healing responses. In late gestation, genome-wide H3K27 demethylation allows for target gene upregulation, decidual activation, and labor entry. Strikingly, pharmacological inhibition of this latter process not only prevented term parturition, but also inhibited delivery while maintaining pup viability in a non-inflammatory model of preterm parturition. Immunofluorescence analysis of human specimens suggested that similar regulatory events might occur in the human decidua. Together, these results reveal the centrality of regulated gene silencing in the uterine adaptation to pregnancy and suggest new areas in the study and treatment of pregnancy disorders.

2017-10-23 | GSE105455 | GEO

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [ChIP-seq]

2017-10-23 | GSE105444 | GEO

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

Project description:H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

| PRJNA415202 | ENA

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [ChIP-seq]

Project description:H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [ChIP-seq]

| PRJNA415198 | ENA

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [RNA-seq]

Project description:H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition [RNA-seq]

| PRJNA415206 | ENA

The Deciphering of Mouse Uterine Microenvironment during Early Pregnancy

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-30 | GSE181170 | GEO

Gene expression profiling of uterine stromal and epithelial cells isolated from Msx1Msx2 floxed and Msx1Msx2 ablated mice on day 4 of pregnancy

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-20 | E-GEOD-30969 | biostudies-arrayexpress

Distinct dynamics and functions of H2AK119ub and H3K27me3 in mouse preimplantation embryos

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-15 | GSE153531 | GEO

Bidirectional changes in postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-11 | GSE212441 | GEO

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