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Transcriptional and epigenetic regulation of adaptive NK cell responses [ChIP-Seq]

ABSTRACT: Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin (IL)-12 signaling through its downstream transcription factor STAT4 is required for the generation of memory NK cells following expansion, while type I interferon through STAT1 is important for NK cell expansion. Here, we identify gene loci that are highly enriched for STAT4 binding using ChIP-seq for STAT4 and the permissive histone mark H3K4me3 in activated NK cells. In addition, we identify gene loci that are high enriched for STAT1 binding in response to type I interferon signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE106137 | GEO | 2017/12/20

SECONDARY ACCESSION(S): PRJNA415720

REPOSITORIES: GEO

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Transcriptional regulation of adaptive NK and CD8 T cell responses [RNA-Seq]

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