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Targeted enhancer activation by a subunit of the integrator complex

ABSTRACT: We investigated the genomic occupancy of INTS13 during monocytic differentiation, in in vitro differentiated monocytes and a leukemia-derived cell line. We produced genome wide data for steady state RNA (total RNA-seq) and chromatin-associated RNA (chromatin RNA-seq). Further, we used ChIP-seq to examine genome-wide distribution of INTS13, INTS11, EGR1 and NAB2, as well as the changes in occupancy of RNAPII, H3K4me1 and H3K27ac.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106359 | GEO | 2018/03/01

REPOSITORIES: GEO

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