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Time course of NHBE cells exposed to whole cigarette smoke

ABSTRACT: Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke from a reference cigarette (2R4F, University of Kentucky) and a typical American brand of "light" cigarettes ("Lights") in order to develop a better understanding of the genomic impact of tobacco exposure, which can ultimately define biomarkers that discriminate tobacco-related effects and outcomes in a clinical setting. NHBE cells were treated with whole cigarette smoke for 15 minutes and alterations to the transcriptome assessed at 2, 4, 8 and 24 hours post-exposure using high-density oligonucleotide microarrays. Keywords: time course, cigarette smoke exposure

ORGANISM(S): Homo sapiens

PROVIDER: GSE10700 | GEO | 2008/03/04

SECONDARY ACCESSION(S): PRJNA107573

REPOSITORIES: GEO

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