Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

ABSTRACT: Comparison of miRNA expression profiles from male Nothobranchius furzeri (strain MZM-0410) hearts in different age groups. The small-RNA-seq data comprises 3 groups

ORGANISM(S): Nothobranchius furzeri

PROVIDER: GSE107062 | GEO | 2018/02/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Longitudinal RNA-Seq study of Nothobranchius furzeri fin biopsies

Project description:Here, we performed a longitudinal study of genome-wide gene expression in the short-lived killifish Nothobranchius furzeri (MZM-0410 strain) and correlated variations in transcript abundance at two time points during early adult life with age at death.

2020-06-24 | GSE150318 | GEO

Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

Project description:The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 week (young), 12-21 week (adult) and 28-40 week (old) Nfu hearts revealed 23 up-regulated and 18 down-regulated miRNAs with age. MiR-29 family turned out as one of the most up-regulated miRNAs during aging. MiR-29 family increase induces a decrease of known targets like collagens and DNA methyl transferases (DNMTs) paralleled by 5´methyl-cytosine (5mC) level decrease. To further investigate miR-29 family role in the fish heart we generated a transgenic zebrafish model where miR-29 was knocked-down. In this model we found significant morphological and functional cardiac alterations and an impairment of oxygen dependent pathways by transcriptome analysis leading to hypoxic marker up-regulation. To get insights the possible hypoxic regulation of miR-29 family, we exposed human cardiac fibroblasts to 1% O2 levels. In hypoxic condition we found miR-29 down-modulation responsible for the accumulation of collagens and 5mC. Overall, our data suggest that miR-29 family up-regulation might represent an endogenous mechanism aimed at ameliorating the age-dependent cardiac damage leading to hypertrophy and fibrosis.

2018-02-27 | GSE107003 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-0410p) skin after Rotenone and DMSO treatment

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-0410p) skin of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise 2 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103139 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-0410p) liver after Rotenone and DMSO treatment

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-0410p) liver of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise 2 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103136 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-0410p) brain after Rotenone and DMSO treatment

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-0410p) brain of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise 2 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103131 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-0410p) brain from microRNA treated animals 2

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-0410p) brain of miRNA treated animals (scrambled control, antagomiR29a). The RNA-seq data comprise 2 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103130 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-0410p) brain from microRNA treated animals 1

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-0410p) brain of miRNA treated animals (scrambled control, antagomiR101a). The RNA-seq data comprise 2 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103129 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-04/10p) skin from Rotenone treated animals in two age groups

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-04/10p) skin for 2 age groups treated with Rotenone and DMSO. The RNA-seq data comprise 4 groups: two age groups, each treated with different Rotenone dose levels. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103819 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-04/10p) brain from Rotenone treated animals in two age groups

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-04/10p) brain for 2 age groups treated with Rotenone and DMSO. The RNA-seq data comprise 4 groups: two age groups, each treated with different Rotenone dose levels. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103804 | GEO

Sequencing of Nothobranchius furzeri liver (strain: MZM-04/10p) from Rotenone treated animals in two age groups

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-04/10p) liver for 2 age groups treated with Rotenone and DMSO. The RNA-seq data comprise 4 groups: two age groups, each treated with different Rotenone dose levels. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103809 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data