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Insulin receptor associates with promoters genome-wide and regulates gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107336 | GEO | 2019/04/04

REPOSITORIES: GEO

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Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression.

Project description:Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid signaling via cytoplasmic kinases. However, mechanisms mediating long-term effects of insulin remain unclear. Here, we show that IR associates with RNA polymerase II in the nucleus, with striking enrichment at promoters genome-wide. The target genes were highly enriched for insulin-related functions including lipid metabolism and protein synthesis and diseases including diabetes, neurodegeneration, and cancer. IR chromatin binding was increased by insulin and impaired in an insulin-resistant disease model. Promoter binding by IR was mediated by coregulator host cell factor-1 (HCF-1) and transcription factors, revealing an HCF-1-dependent pathway for gene regulation by insulin. These results show that IR interacts with transcriptional machinery at promoters and identify a pathway regulating genes linked to insulin's effects in physiology and disease.

| S-EPMC6478446 | biostudies-literature

Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

Project description:ChIP-seq analysis demonstrates an association of insulin receptor (IR) and RNA polymerase II on chromatin, with striking enrichment at gene promoters.

2019-04-04 | GSE107335 | GEO

Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

Project description:RNA-seq analysis identifies transcripts regulated by insulin treatment.

2019-04-04 | GSE107334 | GEO

Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]

Project description:RNA-seq analysis identifies transcripts regulated by HCF-1 expression

2019-04-04 | GSE124845 | GEO

Insulin receptor associates with promoters genome-wide and regulates gene expression

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression

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Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

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Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

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Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]

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Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ES cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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FGFR1 associates with gene promoters and regulates gene transcription: Implications for endocrine resistance in ER+/FGFR1-amplified breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

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