Genomics

Dataset Information

0

Epigenetic profiling of human HAP1 cells before and after nutrient deprivation


ABSTRACT: Autophagy is a lysosomal degradation pathway critical for maintaining cellular homeostasis and viability, and is predominantly regarded as a rapid and dynamic cytoplasmic process. To improve our understanding of the transcriptional and epigenetic events associated with autophagy, we performed genome-wide transcriptomic and epigenomic profiling after nutrient deprivation in human wildtype and autophagy-deficient cells. We observed that nutrient deprivation leads to the transcriptional induction of numerous autophagy-associated genes. These transcriptional changes are reflected at the epigenetic level (H3K4me3, H3K27ac, and H3K56ac) and are independent of autophagic flux.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107599 | GEO | 2018/09/28

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-09-28 | GSE107600 | GEO
2021-08-24 | GSE176075 | GEO
2021-08-24 | GSE176074 | GEO
| PRJNA420748 | ENA
| PRJNA420678 | ENA
2021-08-24 | GSE176073 | GEO
2014-09-27 | E-GEOD-61817 | biostudies-arrayexpress
2022-06-23 | GSE193392 | GEO
2022-06-23 | GSE193217 | GEO
2022-06-23 | GSE193215 | GEO