Analysis of somatic copy number alterations in ApcΔ716 mouse intestinal tumors [aCGH]
Ontology highlight
ABSTRACT: To detect somatic copy number alterations in APC mutant tumors, we analyzed intestinal tumors from heterozygous ApcΔ716 mice, in which polyposis initiates upon loss of heterozygosity without losing the mutant allele (Proc Natl Acad Sci U S A. 1995 May 9;92(10):4482-6).
Project description:Series of 6 repetitions of hybridization of treatment (psbs) and control (WT) each. Comparison of the Arabidopsis psbs mutant lacking Photosystem I protein PSII-S versus WT. X.P. Li et al., Proc Natl Acad Sci U S A 99 (2002), pp. 15222-15227 Keywords: repeat sample
Project description:Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance. Proc. Natl. Acad. Sci. USA. (2004) Keywords: time-course
Project description:Series of 6 repetitions of hybridization of treatment (fluD) and control (WT) each. Comparison of Arabidopsis flu mutant lacking FLU, a regulator of chlorophyll biosynthesis, versus WT. Both harvested after a period of 12 h darkness. R. Meskauskiene et al., Proc Natl Acad Sci U S A 98 (2001), pp. 12826-12831 Keywords: repeat sample
Project description:Additional experiments used for intrinsic gene selection. Sorlie et al. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74. This Series accompanies Series GSE4335. Experiments that were used to make the "intrinsic" gene list from. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set
Project description:Series of 6 repetitions of hybridization of treatment (fluL) and control (WT) each. Comparison of Arabidopsis flu mutant lacking FLU, a regulator of chlorophyll biosynthesis versus WT. Both harvested 30' after reexposure to light after 12h dark period. R. Meskauskiene et al., Proc Natl Acad Sci U S A 98 (2001), pp. 12826-12831 Keywords: repeat sample
Project description:Series of 8 repetitions of hybridization of treatment (gun5) and control (WT) each. Comparison of Arabidopsis gun5 mutant lacking a ChlH subunit of Mg-chelatase versus WT. R.E. Susek et al., Cell 74 (1993), pp. 787-799; N. Mochizuki et al., Proc Natl Acad Sci U S A 98 (2001), pp. 2053-2058 Keywords: repeat sample
Project description:This is a training data set for destructin-1 protease digestion of a synthetic peptide library for substrate specificity profiling. Data is related to the following publication:
O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik
CS, Bennett RJ. "Destructin-1 is a collagen-degrading endopeptidase secreted by
Pseudogymnoascus destructans, the causative agent of white-nose syndrome." Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7478-83. doi: 10.1073/pnas.1507082112.
Epub 2015 May 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3152.
PMCID: PMC4475985.
Project description:We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transformation in vitro and in vivo. These data suggest that EZH2 might play a central role in Ewing Tumor pathology.
Project description:Series of 6 repetitions of hybridization of treatment (psbs) and control (WT) each. Comparison of the Arabidopsis psbs mutant lacking Photosystem I protein PSII-S versus WT. X.P. Li et al., Proc Natl Acad Sci U S A 99 (2002), pp. 15222-15227 Keywords: repeat sample
Project description:The ultraconserved RNA TUC338 is expressed in hepatocellular cancer and can modulate cell proliferation. Details are provided in Braconi et al,Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):786-91. In this analysis, we knocked down TUC338 in HepG2 cells and analyzed gene expression.