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Cardiac microarray changes in a transgenic mouse expressing a human mitochondrial progesterone receptor (PR-M).

ABSTRACT: A TET-On transgenic mouse model was develop for cardiac expression of a human mitochondrial progesterone receptor (PR-M). Expression was verified by immunohistochemistry and RT-PCR. Previous research with cell knockdown and overexpression has shown a ligand dependent increase in cellular respiration with this receptor. Mice expressing (N=3) or not expressing (N=3) PR-M were treated with progesterone for 19-21 days prior to sacrifice. Tissue from the apical cardiac ventrical was submitted for microarray.

ORGANISM(S): Mus musculus

PROVIDER: GSE108551 | GEO | 2017/12/27

SECONDARY ACCESSION(S): PRJNA427599

REPOSITORIES: GEO

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