Transcriptomics

Dataset Information

0

Expression data from decoy receptor 3-treated monocyte-derived macrophages


ABSTRACT: Decoy receptor 3 (DcR3) is a member of the TNF receptor superfamily and is up-regulated in tumors that originate from a diversity of lineages. DcR3 is capable of promoting angiogenesis, inducing dendritic cell apoptosis, and modulating macrophage differentiation. Since tumor-associated macrophages (TAMs) are the major infiltrating leukocytes in most malignant tumors, we used microarray technology to investigate whether DcR3 contributes to the development of TAMs. Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)-dependent antigen presentation were down-regulated substantially, together with the master regulator of MHC-II expression (the class II transactivator, CIITA). The ERK- and JNK-induced deacetylation of histones associated with the CIITA promoters was responsible for DcR3-mediated down-regulation of MHC-II expression. Furthermore, the expression level of DcR3 in cancer cells correlated inversely with HLA-DR levels on TAMs and with the overall survival time of pancreatic cancer patients. The role of DcR3 in the development of TAMs was further confirmed using transgenic mice over-expressing DcR3. This elucidates the molecular mechanism of impaired MHC-II-mediated antigen presentation by TAMs, and raises the possibility that subversion of TAM-induced immunosuppression via inhibition of DcR3 expression might represent a target for the design of new therapeutics. Keywords: time-dose response

ORGANISM(S): Homo sapiens

PROVIDER: GSE10856 | GEO | 2008/03/18

SECONDARY ACCESSION(S): PRJNA107355

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-04-05 | E-GEOD-10856 | biostudies-arrayexpress
2017-06-09 | GSE99397 | GEO
2010-12-18 | E-MTAB-192 | biostudies-arrayexpress
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
2023-12-18 | GSE246253 | GEO
2022-10-02 | GSE189772 | GEO
2022-10-02 | GSE189769 | GEO
2022-10-02 | GSE189767 | GEO
2022-10-02 | GSE189771 | GEO
2016-10-04 | MSV000080228 | MassIVE