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Profiling of long non-coding RNAs associated with atrial fibrillation in patients with rheumatic heart valvular disease

ABSTRACT: To investigate the expression profiles of long non-coding RNAs (lncRNAs) in atrial fibrillation (AF), atrial tissues from 5 AF patients and 5 non-AF patients that were collected for lncRNA expression microarray analyses to explore the role of lncRNA in the pathogenesis of AF.rhythm (SR) patients with rheumatic heart valvular disease,we have employed

ORGANISM(S): Homo sapiens

PROVIDER: GSE108660 | GEO | 2018/01/03

SECONDARY ACCESSION(S): PRJNA428217

REPOSITORIES: GEO

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Comparison of atrial appendage tissues of patients with Valvular Heart Disease and patients with Valvular Heart Disease-Atrial Fibrillation

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Valvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently

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2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress

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Project description:Atrial fibrillation (AF) is the most common persistent arrhythmia that affect 1–2% of the general population. People with AF display an array of complications cardiogenic stroke and systemic embolism caused by hemodynamic instability and blood hypercoagulability in clinical practice. However, it’s still unclear whether and how ubiquitylated proteins react to AF in the left atrial appendage of patients with AF and valvular heart disease. This theory focuses on the changes of ubiquitylated proteins in atrial fibrillation associated with heart valve disease. We firstly widely analysis the proteins ubiquitination in patients with atrial fibrillation.

2021-12-24 | PXD030397 | Pride

Valvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently

2011-12-21 | GSE28954 | GEO

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Profiling of long non-coding RNAs associated with atrial fibrillation in patients with rheumatic heart valvular disease

Project description:Profiling of long non-coding RNAs associated with atrial fibrillation in patients with rheumatic heart valvular disease

| PRJNA428217 | ENA

Integrated Analysis of Dysregulated lncRNA and mRNA Expression profiles of myocardial sleevesof pulmonary veins in atrial fibrillation

Project description:Atrial fibrillation (AF) is currently the most prevalent arrhythmia worldwide.Recent clinical data implicate the additional contribution of non-coding RNAs in the pathogenesis of AF，which include microRNAs(miRNAs), endogenous small interfering RNAs, PIWIinteracting RNAs, and lncRNA. Notably, a growing number of lncRNAs have been implicated in disease etiology, although an association with AF has not been reported. In the present study, we conducted an integrated analysis of dysregulated lncRNA and mRNA expression profiles in myocardial sleevesof pulmonary veins between the patients who develop AF and the patients who were in normal sinus rhythm, which was performed using a second generation lncRNA microarray，focusing specifically on the identification and characterization of lncRNAs and mRNA potentially involving in maintaining atrial fibrillation.

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