Genomics

Dataset Information

0

Genome-wide maps of chromatin state in HCT116 cells.


ABSTRACT: We identified KDM3A, a demethylase of histone H3K9me1/2, as a positive regulator for hippo target genes. We found that H3K27ac upregulation is highly correlated with gene activation, but not H3K4me3; and transcription repression of certain TEAD1 target genes, such as BBC3, is important for the pathway function. KDM3A knockout caused upregulation of H3K9me2 mainly on TEAD1-binding enhancers rather than gene bodies, leading to decrease of H3K27ac and TEAD1 binding on enhancers and impaired transcription. We identified KDM3A, a demethylase of histone H3K9me1/2, as a positive regulator for hippo target genes. We found that H3K27ac upregulation is highly correlated with gene activation, but not H3K4me3; and transcription repression of certain TEAD1 target genes, such as BBC3, is important for the pathway function. KDM3A knockout caused upregulation of H3K9me2 mainly on TEAD1-binding enhancers rather than gene bodies, leading to decrease of H3K27ac and TEAD1 binding on enhancers and impaired transcription.

ORGANISM(S): Homo sapiens

PROVIDER: GSE108920 | GEO | 2019/03/20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-03-20 | GSE108921 | GEO
2015-08-25 | E-GEOD-61852 | biostudies-arrayexpress
2014-10-15 | E-GEOD-62309 | biostudies-arrayexpress
2014-10-15 | GSE62309 | GEO
2024-04-13 | PXD045644 | Pride
2010-07-14 | E-GEOD-21108 | biostudies-arrayexpress
2010-07-14 | E-GEOD-21555 | biostudies-arrayexpress
2010-07-14 | GSE21108 | GEO
2010-07-14 | GSE21555 | GEO
2023-08-16 | GSE186521 | GEO