Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exon Level Expression Profiling in Kawasaki disease (KD): gene expression profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

ABSTRACT: Transcriptome analysis of pooled RNA samples from total WBC collection The RNA samples from six subjects were evenly pooled into one pooled one, followed by sample preparation and microarray experiment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109351 | GEO | 2018/10/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

DNA methylation Profiling in Kawasaki disease (KD): DNA methylation profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

Project description:DNA methylation analysis of DNA samples from total WBC collection The DNA samples from each subject was first subject to bisulfite conversion, followed by sample preparation and microarray experiment.

2018-10-21 | GSE109430 | GEO

Exon Level Expression Profiling in Kawasaki disease (KD): gene expression profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

Project description:Exon Level Expression Profiling in Kawasaki disease (KD): gene expression profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

| PRJNA430537 | ENA

DNA methylation Profiling in Kawasaki disease (KD): DNA methylation profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

Project description:DNA methylation Profiling in Kawasaki disease (KD): DNA methylation profile in healthy control subjects, acute-phase KD subjects and convalescent-phase KD subjects

| PRJNA430873 | ENA

Psoriasiform eruptions during Kawasaki disease (KD): A distinct phenotype.

Project description:BackgroundA psoriasis-like eruption develops in a subset of patients with Kawasaki disease (KD).ObjectiveWe sought to systematically compare KD-associated psoriasiform eruptions with classic psoriasis and the outcomes of KD in children with and without this rash.MethodsThis was a retrospective study of 11 KD cases with a psoriasiform eruption matched 1:2 by age, gender, and ethnicity with psoriasis-only and KD-only controls. Genotyping was performed in 10 cases for a deletion of 2 late cornified envelope (LCE) genes, LCE3C_LCE3B-del, associated with increased risk for pediatric-onset psoriasis.ResultsSimilar to classic psoriasis, KD-associated eruptions were characterized clinically by well-demarcated, scaly pink plaques and histopathologically by intraepidermal neutrophils, suprabasilar keratin 16 expression, and increased Ki-67 expression. They showed less frequent diaper area involvement, more crust and serous exudate, and an enduring remission (91% vs 23% with confirmed resolution; P < .001). Frequency of LCE3C_LCE3B-del and major KD outcomes were similar between cases and controls.LimitationsThe study was limited by the small number of cases, treatment variation, and availability of skin biopsy specimens.ConclusionsAlthough the overall clinical and histopathologic findings were similar to conventional psoriasis, this appears to be a distinct phenotype with significantly greater propensity for remission. No adverse effect on KD outcomes was noted.

| S-EPMC4912865 | biostudies-literature

DNA methylation Profiling in Autoimmune encephalitis (AE): DNA methylation profile in healthy control (HC) sujects and acute-phase AE subjects

2019-10-25 | GSE132866 | GEO

Gene expression of CD8+ T cells isolated from human subjects during acute and convalescent phase of EBV infection

Project description:Affymetrix HuGene ST 1.0 microarrays were used to study and compare gene expression in peripheral blood CD8+ T cells of human patients with Acute Infectious Mononucleosis (AIM; acute EBV infection) and during convalescence (CONV; 6-12 months after AIM visit). Blood samples were drawn from ten human patients with AIM and again during their covalescence (CONV). Peripheral blood mononuclear cells were isolated and cryopreserved. Paired AIM and CONV samples were thawed and CD8+ T cells purified with magnetic beads. RNA was isolated and processed for hybridization according to the Affymetrix protocol

2015-07-22 | GSE71045 | GEO

Gene expression of CD8+ T cells isolated from human subjects during acute and convalescent phase of EBV infection

2015-07-22 | E-GEOD-71045 | biostudies-arrayexpress

MicroRNA profile of exosome from serum samples of Kawasaki disease

Project description:To further development of our miRNA diagnostic approach to Kawasaki disease(KD), we have employed microRNA microarray expression profiling as a discovery platform to identify microRNAs as the potential biomarkers to rapidly diagnose Kawasaki disease. Pooled exosome of serum in equal amount from 5 healthy children, 5 KD patients and 5 KD patients after Intravenous immunoglobulin (IVIG) therapy were used for microRNA microarray analysis.

2014-09-03 | GSE60965 | GEO

Cardiac magnetic resonance feature tracking of the right ventricle in convalescent Kawasaki disease in a large single center.

Project description:BackgroundThe changes in right ventricular (RV) contractility of Kawasaki disease (KD) still remain unclear.HypothesisWe aimed to determine whether RV systolic dysfunction can be detected by cardiac magnetic resonance (CMR) feature tracking and to find its association with coronary artery lesions (aneurysm, thrombosis and stenosis).MethodsPeak systolic myocardial longitudinal, radial and circumferential strain and the strain rate (RVSL, RVSR, RVSC, RVSRL, RVSRR and RVSRC) in the global RV and three levels (basal, middle and apical) were measured in 66 patients with convalescent KD. A total of 20 controls were included. Comparisons were made with controls and among KD subgroups divided with coronary artery lesions.ResultsRVSC (-10.575% vs. -10.760%), RVSL (-18.150% vs. -18.712%) and RVSRC (-0.815/s vs. -0.924/s) were slightly lower in KD group without significant difference. All the strain and strain rate presented lowest in the basal level. In subgroup comparison, lower RVSL and RVSRL were observed in the giant coronary artery aneurysm (CAA) group; RVSR (15.844% vs. 16.897%), RVSRR (1.245/s vs. 1.322/s) and RVSRC (-0.715/s vs. -0.895/s) were lower in thrombosed group; RVSRL (-1.27/s vs. -1.503/s) were lower in stenosis group. All the comparison in subgroups did not reach significant difference. From the analysis of receiver operating characteristic curve, RVSRL had a better ability to identify KD with giant CAA and stenosis. For the identification of thrombosis, RVSRC had a better ability.ConclusionsLower strain and strain rates of RV were detected in convalescent KD. More pronounced in those with persisting coronary artery lesions.

| S-EPMC7803351 | biostudies-literature

Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice.

Project description:BackgroundMice that are homozygous for the kidney disease (kd) mutation are apparently healthy for the first 8 weeks of life, but spontaneously develop a severe form of interstitial nephritis that progresses to end-stage renal disease (ESRD) by 4 to 8 months of age. By testing for linkage to microsatellite markers, we previously localized the kd gene to a YAC/BAC contig.MethodsThe sequence of the entire critical region was examined, and candidate genes were identified. These candidate genes were sequenced in both mutant (kd/kd) mice and normal controls. The phenotype was further characterized by immunohistochemistry and electron microscopy. Transgenic mice were constructed that carried the wild-type allele of the prime candidate gene, and this transgene was transferred to a kd/kd background by breeding.ResultsWe have obtained evidence that kd is a mutant allele of a novel gene for a prenyltransferase-like mitochondrial protein (PLMP). This gene is alternatively spliced, with the larger gene product having one domain that resembles transprenyltransferase and another that is similar to geranylgeranyl pyrophosphate synthase. The smaller gene product includes only the first domain. An antiserum to PLMP localizes to mitochondria, and ultrastructural defects are present in the mitochondria of renal tubular epithelial cells, and to a lesser extent, hepatocytes and heart cells from kd/kd mice. In a line of kd/kd mice that carried the wild-type PLMP allele as a transgene, only 1 out of 13 animals expressed the disease by 120 days of age.ConclusionThe kd allele codes for a novel protein that localizes to the mitochondria, and the kd/kd mouse has dysmorphic mitochondria in the renal tubular epithelial cells. This mouse is therefore a unique animal model for studying mechanisms that lead to tubulointerstitial nephritis.

| S-EPMC2254219 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data