Transcriptome analysis of VCaP xenografts resistant to dual therapy with abiraterone and enzalutamide
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ABSTRACT: We report RNA sequencing data on serial biopsies of prostate cancer VCaP xenografts as the tumors pass from androgen-sensitivity (Pre-Cx), to castration resistance (CRPC, castration resistant prostate cancer), onto resistance to dual therapy with abiraterone plus enzalutamide (AER). From comparison of these RNAseq data sets, we were able to determine differentially expressed genes between the AER/CRPC and Pre-Cx states that could mediate resistance to androgen deprivation therapies.
ORGANISM(S): Homo sapiens
PROVIDER: GSE109708 | GEO | 2018/12/26
REPOSITORIES: GEO
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