Transcriptomics,Multiomics

Dataset Information

0

Increased Serine and One Carbon Pathway Metabolism by PKCl/i Deficiency Promotes Neuroendocrine Prostate Cancer [MicroArray]


ABSTRACT: Increasingly effective therapies targeting the androgen receptor have paradoxically promoted the incidence of neuroendocrine prostate cancer (NEPC), the most lethal subtype of castration-resistant prostate cancer (PCa), for which there is no effective therapy. Here we report that protein kinase C (PKC)l/i is downregulated in de novo and during therapy-induced NEPC, which results in the upregulation of serine biosynthesis through an mTORC1/ATF4-driven pathway. This metabolic reprogramming increases intracellular SAM levels to support cell proliferation and epigenetic changes that favor the development of NEPC characteristics. Altogether, we have uncovered a metabolic vulnerability triggered by PKCl/i deficiency in NEPC, which offers potentially actionable targets to prevent therapy resistance in PCa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109751 | GEO | 2019/03/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-03-05 | GSE109758 | GEO
2019-03-05 | GSE109752 | GEO
2019-03-05 | GSE109763 | GEO
2015-01-15 | E-GEOD-61214 | biostudies-arrayexpress
2024-03-31 | GSE261370 | GEO
2024-09-01 | GSE271777 | GEO
2024-09-01 | GSE271776 | GEO
2024-08-01 | GSE235036 | GEO
2024-08-28 | GSE234819 | GEO
2016-02-06 | E-GEOD-77624 | biostudies-arrayexpress