Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Molecular Dissection of the Oncogenic Role of ETS1 in the Mesenchymal Subtypes of Head and Neck Squamous Cell Carcinoma [RNA-seq Cell lines]

ABSTRACT: RNA-Sequencing Analysis was performed on 7 Head and Neck Squamous Cell Carcinoma Cells Lines in order to examine their overall gene expression profiles.

ORGANISM(S): Homo sapiens

PROVIDER: GSE109885 | GEO | 2019/07/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profiles of head and neck squamous cell carcinoma

Project description:Sage performed on microdissection of Head and Neck tumor, and Head and Neck normal tissue comparative analysis of gene expression profiles of head and neck squamous cell carcinoma and Head and Neck normal tissue

2008-09-30 | E-GEOD-11986 | biostudies-arrayexpress

Gene expression profiles of Head & Neck Squamous and Lung Squamous Cancers

Project description:The differential diagnosis between head & neck squamous cell carcinomas and lung squamous cell carcinomas is often unresolved because the histologic appearance of these two tumor types is similar. In the development of a gene expression profile test (GEP-HN-LS) that distinguishes these 2 cancer types, a collection of poorly differentiated primary and metastatic tumor specimens were used. Here we describe 76 such tumor specimens that were used for validation of GEP-HN-LS. The specimens are either head & neck squamous cell carcinomas or lung squamous cell carcinomas.

2013-03-10 | GSE44170 | GEO

Gene expression profiles of Head & Neck Squamous and Lung Squamous Cancers

2013-03-10 | E-GEOD-44170 | biostudies-arrayexpress

Head and neck squamous cell carcinoma extracelular vesicles proteome LC-MS

Project description:Monitoring of changes in the proteomic composition of extracellular vesicles produced by head and neck squamous cell carcinoma cells after exposure to agents affecting autophagic and lysosomal processes. LC-MS analysis of phosphatidylserine-positive budding EVs.

2023-05-25 | PXD037164 | Pride

Transcription profiling of human squamous cell carcinoma of head and neck

Project description:Gene Expression Analysis of Squamous Cell Carcinoma of Head and Neck

2008-06-12 | E-GEOD-2326 | biostudies-arrayexpress

scRNA-sequencing from HPV-positive head and neck squamous cell carcinomas

Project description:We report single cell transcriptome data from HPV-positive head and neck squamous cell carcinoma patients

2023-06-20 | GSE173468 | GEO

MicroRNA-based subtypes in head and neck squamous cell carcinoma

Project description:MicroRNA-based subtypes in head and neck squamous cell carcinoma

| PRJNA604621 | ENA

Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma.

Project description:Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease of significant mortality and with limited treatment options. Recent genomic analysis of HNSCC tumors has identified several distinct molecular classes, of which the mesenchymal subtype is associated with Epithelial to Mesenchymal Transition (EMT) and shown to correlate with poor survival and drug resistance. Here, we utilize an integrated approach to characterize the molecular function of ETS1, an oncogenic transcription factor specifically enriched in Mesenchymal tumors. To identify the global ETS1 cistrome, we have performed integrated analysis of RNA-Seq, ChIP-Seq and epigenomic datasets in SCC25, a representative ETS1high mesenchymal HNSCC cell line. Our studies implicate ETS1 as a crucial regulator of broader oncogenic processes and specifically Mesenchymal phenotypes, such as EMT and cellular invasion. We found that ETS1 preferentially binds cancer specific regulator elements, in particular Super-Enhancers of key EMT genes, highlighting its role as a master regulator. Finally, we show evidence that ETS1 plays a crucial role in regulating the TGF-β pathway in Mesenchymal cell lines and in leading-edge cells in primary HNSCC tumors that are endowed with partial-EMT features. Collectively our study highlights ETS1 as a key regulator of TGF-β associated EMT and reveals new avenues for sub-type specific therapeutic intervention.

| S-EPMC6657958 | biostudies-literature

MiRNA array based, miRNA expression profiles of head and neck squamous cell carcinoma patients

Project description:MiRNA expression profiles were successfully examined through expression profiling of a total of 656 miRNAs between 2 head and neck squamous cell carcinoma (HNSCC) tissues (C) and their paired adjacent normal mucousal tissues (AN). In the study presented here, 2 head and neck squamous cell carcinoma (HNSCC) tissues (C) and their paired adjacent normal mucousal tissues (AN) were examined by miRNA array

2011-09-14 | E-GEOD-32115 | biostudies-arrayexpress

MeDIP-chip from head and neck squamous cell carcinoma tissues and normal subjects

Project description:Profiling the genome-wide methylation status of head and neck squamous cell carcinoma and normal subjects

2014-06-19 | GSE58630 | GEO