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Establishment of novel atopic dermatitis model by Nestin-cre mediated Ikk2 deficiency

ABSTRACT: To generate novel atopic dermatitis model, we used Nestin-cre mediated Ikk2FL/FL mice. Nestincre-mediated conditional knockout mice of Ikk2 gene were generated by crossing female Ikk2FL/FL mice to male Nestin-cre;Ikk2FL/+mice. Nestin-cre;Ikk2FL/FL mice spontaneously develop chronic AD-like skin inflammation and severe pruritus. We further performed Cap analysis of gene expression (CAGE) to elucidate transcriptional profiles in lesional skin of Nestin-cre;Ikk2FL/FL mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE109936 | GEO | 2020/01/26

REPOSITORIES: GEO

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Establishment of novel atopic dermatitis model by Nestin-cre mediated Ikk2 deficiency

Project description:Establishment of novel atopic dermatitis model by Nestin-cre mediated Ikk2 deficiency

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Expression data comparing the effect of IKK2 KO on a KRAS mouse model

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