Impaired TNFa-driven dendritic cell activation limits LPS-induced protection from asthma in infants.
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ABSTRACT: We found that approximately 200 genes were differentially expressed between CD11b+ lung-migratory dendritic cells (CD11b+ mDCs) from adult and infant mice treated with house dust mite allergen + LPS, and that the TNFa-via NFkB signaling pathway was significantly enriched in CD11b+ mDCs from adults relative to those from infants. Specifically, out of the 200 genes in the hallmark TNFa-via NFkB signaling pathway that were analyzed, 31 genes were significantly downregulated in CD11b+ mDCs from infants compared to CD11b+ mDCs from adults.
ORGANISM(S): Mus musculus
PROVIDER: GSE110046 | GEO | 2019/01/08
REPOSITORIES: GEO
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