Methylation profiling

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CpG DNA methylation is altered in the PKD1 gene body but not promoter in autosomal dominant polycystic kidney disease


ABSTRACT: Limited data exists on alterations in DNA methylation that are associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Given there are similarities between cystic kidney disease and neoplasia, and that DNA methylation inhibitors are FDA-approved for the treatment of myelodysplastic syndrome, we performed genome-scale methylation analysis of cortical kidney tissue from four ADPKD patients and nonADPKD cortical kidney tissue from three individuals to identify the methylation patterns of ADPKD tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110057 | GEO | 2019/12/01

REPOSITORIES: GEO

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