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Expression profiling in exosomal miRNAs of human bone marrow stromal cells derived from multiple myeloma patients

ABSTRACT: Bone marrow stromal cells (BMSCs) and their exosomes are a promising area of cancer therapy. Multiple myeloma (MM) is refractory hematologic malignancy. Bone marrow stromal cells (BMSCs) interact with MM cells in the bone marrow (BM), and also create a permissive microenvironment for MM cell growth and survival. Recent evidence indicated that exosome-mediated MM cell-BMSC communication plays an important role in the MM microenvironment. In this study, we investigated the biological property of the exosomes and exosomal miRNAs derived from BMSCs, aiming to establish the emerging strategies to target MM microenvironment to prevent tumor growth and spread.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110271 | GEO | 2018/06/08

REPOSITORIES: GEO

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