Transcriptomics,Multiomics

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Single-cell transcriptome analyses reveal endothelial cell heterogeneity in tumors and changes following anti-angiogenic treatment


ABSTRACT: To understand tumor stromal cell heterogeneity focusing on tumor endothelial cells and tumor-associated fibroblasts, we isolated single cells from COLO205 tumor xenograft grown sub-cutaneously in SCID mice. To enrich stromal cell content, we removed vast majority of tumor cells by a depletion protocol using anti-CD24 and anti-E-Cadherin antibodies. The remaining single cells were profiled by single cell RNAseq

OTHER RELATED OMICS DATASETS IN: PRJNA433865

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE110501 | GEO | 2018/02/28

REPOSITORIES: GEO

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