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Inhibiting WNT and NOTCH in renal cancer stem cells: implications for human patients

ABSTRACT: We detected and characterized CXCR4+MET+CD44+ cancer stem cells (CSCs) that were quantitatively correlated with aggressive tumors. Transcriptional profiling and single-cell sequencing revealed a strong activation of WNT and NOTCH signaling in these CSCs. CEL-Seq was performed to study heterogeneity of the CXCR4+MET+CD44+ population.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110680 | GEO | 2020/01/19

REPOSITORIES: GEO

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