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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

ABSTRACT: This study assessed the global gene-level expression of human mural granulosa cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE110922 | GEO | 2021/02/10

REPOSITORIES: GEO

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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:This study assessed the global gene-level expression of human mural granulosa cells.

2021-02-10 | GSE110919 | GEO

Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 CUMULUS]

Project description:This study assessed the global gene-level expression of human cumulus granulosa cells.

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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of a Mixture of 10 PBDE Congeners Quantified in Follicular Fluid [10-PBDE_MURAL]

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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-153 Quantified from Follicular Fluid [BDE-153 MURAL]

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Differential Gene Expression of Human Cumulus Granulosa and Mural Granulosa Cells in ICSI Patients

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Differential Gene Expression of Human Cumulus Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 CUMULUS]

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Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

Project description:Differential Gene Expression of Human Mural Granulosa Cells in ICSI Patients Exposued to Low or High Environmental Levels of BDE-47 Quantified from Follicular Fluid [BDE-47 MURAL]

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Small RNA sequencing of human preovulatory cumulus and mural granulosa cells

Project description:The granulosa cells in the mammalian ovarian follicle respond to gonadotropin signalling and are involved in the processes of folliculogenesis and oocyte maturation. Studies on gene expression and regulation in human granulosa cells are of interest due to their potential for estimating the oocyte viability and IVF success. However, the post-transcriptional gene expression studies on miRNA level in the human ovary have been scarce. The current study determined the miRNA profile by deep sequencing of the two intrafollicular somatic cell types: mural and cumulus granulosa cells isolated from women undergoing controlled ovarian stimulation and in vitro fertilization. Paired cumulus and mural granulosa samples were analysed from 3 women participating in IVF procedure. Libraries of all 6 samples were sequenced twice, generating 2 technical replicates for each sample. Differential gene expression study was performed on the pooled results of technical replicates.

2013-08-05 | E-GEOD-46489 | biostudies-arrayexpress

Rhesus monkey cumulus cells revert to a mural granulosa cell state following an ovulatory stimulus

Project description:Follicular somatic cells (mural granulosa cells and cumulus cells) and the oocyte communicate through paracrine interactions and through direct gap junctions between oocyte and cumulus cells. Considering that mural and cumulus cells arise through a common developmental pathway and that their differentiation is essential to reproductive success, understanding how these cells differ is a key aspect to understanding their critical functions. Changes in global gene expression before and after an ovulatory stimulus were compared between cumulus and mural granulosa cells to test the hypothesis that mural and cumulus cells are highly differentiated at the time of an ovulatory stimulus and further differentiate during the periovulatory interval. The transcriptomes of the two cell types were markedly different (>1500 genes) before an ovulatory hCG bolus but converged after ovulation to become completely overlapping. The predominant transition was for the cumulus cells to become more like mural cells after hCG. This indicates that the differentiated phenotype of the cumulus cell is not stable and irreversibly established but may rather be an ongoing physiological response to the oocyte. We compared transcriptomes of mural granulosa cells isolated from the follicles before (PM-GC) and after (VVM-GC) an ovulatory stimulus. These data were analyzed with previously published cumulus cells data to compare transitions in granulosa cell state before and after an ovulatory stimulus with transitions in cumulus cells.

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High-throughput RNA sequencing of human preovulatory cumulus and mural granulosa cells (mRNA)

Project description:The granulosa cells in the mammalian ovarian follicle respond to gonadotropin signalling and are involved in the processes of folliculogenesis and oocyte maturation. Studies on gene expression and regulation in human granulosa cells are of interest due to their potential for estimating the oocyte viability and IVF success. The current study determined the mRNA profile by deep sequencing of the two intrafollicular somatic cell types: mural and cumulus granulosa cells isolated from women undergoing controlled ovarian stimulation and in vitro fertilization. Paired cumulus and mural granulosa samples were analysed from 3 women participating in IVF procedure. Differential gene expression study was performed. The identified gene expression profile was also used for predicting targets for miRNAs that were also identified from the same samples (GSE46489).

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